Medical Definition of Q-banding
1.
| A fluorescent stain for chromosomes which produces specific banding patterns for each pair of homologous chromosomes.
The acridine dye derivative, quinacrine hydrochloride, or other derivatives like quinacrine mustard dihydrochloride produces a green-yellow fluorescence at pH 4.5 in chromosome segments rich in constitutive heterochromatin with deoxyadenylate-deoxythymidilate (A-T) bases of DNA.
The centromeric regions of human chromosomes 3, 4, and 13 are specifically stained, as are satellites of some acrocentric chromosomes and the end of the long arm of the Y chromosome.
Banding patterns are similar to those obtained with G-banding stain and similar fluorescent stain results are seen with the antibiotics adriamycin and daunomycin, as well as the tertiary dyes butyl proflavine and dapi, and the bisbenzimidazole dye hoechst 33258.
See: banding patterns, Q bands, quinacrine.
Synonym: quinacrine chromosome banding stain.
(12 Jul 2000)
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Lexicographical Neighbors of Q-banding
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