Definition of Antithrombin
1. Noun. A small molecule that inactivates several enzymes of the coagulation system. ¹
¹ Source: wiktionary.com
Definition of Antithrombin
1. [n -S]
Medical Definition of Antithrombin
1. A plasma glycoprotein that inhibits the proteolytic activity of thrombin such that blood does not coagulate. A deficiency of antithrombin results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis. Antithrombin III, an antithrombin at present somewhat conjectural and biochemically not well characterised. Deficiency is commonly inherited as an autosomal dominant trait; one of the few known mendelizing disorders to which thrombotic disease occurs. Normal antithrombin, an antithrombin naturally occurring in blood and certain tissues under normal conditions in contrast to abnormal states or antithrombin from other sources. (05 Mar 2000)
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Lexicographical Neighbors of Antithrombin
Literary usage of Antithrombin
Below you will find example usage of this term as found in modern and/or classical literature:
1. The Harvey Lectures by Harvey Society of New York, New York Academy of Medicine (1922)
"Contrary to our assumption, Howell thinks that the lipoid is' not a constituent of thrombin, but acts because capable of neutralizing the antithrombin, ..."
2. Therapeutic Gazette (1912)
"If antithrombin is a constant constituent of blood one may assume that it plays an important rôle in maintaining the normal fluidity of this liquid. ..."
3. Physiology and Biochemistry in Modern Medicine by John James Rickard Macleod (1922)
"The source of antithrombin in the body appears to be mainly at least the liver, for it has been found: (1) that peptone injection into an animal from which ..."
4. Thyroid and Thymus by André Crotti (1922)
"From this it will be seen that the available quantity of prothrombin in the blood depends upon the proportions of thromboplastic substances and antithrombin ..."
5. A Text-book of physiology: For Medical Students and Physicians by William Henry Howell (1915)
"As regards the antithrombin present in normal human blood it is important to ... The presence of the antithrombin prevents the activation of the prothrombin ..."
6. Progressive Medicine by Hobart Amory Hare (1917)
"antithrombin amounts were compared by the antithrombin factor, a figure obtained by dividing the coagulation time of a given fibrinogen solution, ..."
7. A Practical treatise on diseases of the skin for the use of students and by Oliver Samuel Ormsby (1921)
"Under experimental conditions, the preservation of this balance may necessitate rapid neutralization of antithrombin excess, or a rapid production of ..."