Medical Definition of Beta-hydroxy-beta-methylglutaryl-CoA

1. -OOCCH2C(OH)(CH3)CH2COS-CoA;a key intermediate in the synthesis of ketone bodies and of steroids. Synonym: 3-hydroxy-3-methylglutaryl-CoA. Beta-hydroxy-beta-methylglutaryl-lyase, an enzyme, found primarily in liver and rumen epithelium that catalyses the formation of acetyl-CoA and acetoacetate from beta-hydroxy-beta-methylglutaryl-CoA; a key step in ketogenesis; a deficiency of this enzyme leads to episodes of severe metabolic acidosis without ketosis. Beta-hydroxy-beta-methylglutaryl-reductase, an enzyme that catalyses the rate-limiting step of cholesterol biosynthesis, beta-hydroxy-beta-methylglutaryl-CoA + 2NADPH + 2H+ → mevalonate + 2NADP+ + coenzyme A. Beta-hydroxy-beta-methylglutaryl-synthase, an enzyme in mitochondria that catalyses the reaction of acetyl-CoA with acetoacetyl-CoA and water to form beta-hydroxy-beta-methylglutaryl-CoA and coenzyme A, a step required for both ketogenesis and steroidogenesis to occur. (05 Mar 2000)

Lexicographical Neighbors of Beta-hydroxy-beta-methylglutaryl-CoA

beta-endorphin
beta-farnesene
beta-farnesene synthase
beta-fructofuranosidase
beta-galactanase
beta-galactosidase
beta-galactoside permease
beta-galactosyl(1-3)N-acetylglucosaminide alpha(2-3)-sialyltransferase
beta-galactosylceramidase
beta-globulins
beta-glucocerebrosidase
beta-glucosidase
beta-glucosyl-hydroxymethylcytosine-alpha-glucosyltransferase
beta-haemolytic streptococci
beta-hydroxy-beta-methylglutaryl-CoA (current term)
beta-hydroxyacyl-(acyl-carrier-protein)dehydrase
beta-hydroxybutyric acid
beta-hydroxyisobutyric acid
beta-hydroxypropionic acid
beta-hydroxypropionic aciduria
beta-hypophamine
beta-interferon
beta-ketoacyl-ACP reductase
beta-ketoacyl-ACP synthase
beta-ketoadipyl-coenzyme A thiolase
beta-ketohydrogenase
beta-ketoreductase
beta-ketothiolase
beta-lactam

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