Medical Definition of Caldesmon

1. Protein originally isolated from smooth muscle (h caldesmon, 120-150 kD on gels but 88.7 kD from sequence) also found in nonmuscle cells (l caldesmon, 70-80 kD on gels but 58.8 kD from sequence). Normally dimeric, binds to F actin blocking the myosin binding site. Calcium calmodulin binding to caldesmon causes its release from actin, though phosphorylation of caldesmon may also affect the link with actin. Caldesmon can block the effect of gelsolin on f actin and will dissociate actin gelsolin complexes and actin profilin complexes. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Caldesmon

calculus II
calculus of variations
calculuses
calcurmolite
calcyclin
calcyphosin
caldaria
caldarium
caldecrin
caldendrin
caldera
calderas
calderite
calderites
calderonite
caldesmon (current term)
caldolase
caldron
caldrons
calean
caleche
caleches
caledonite
calefacient
calefacients
calefaction
calefactions
calefactive
calefactories
calefactory

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