Definition of Calpain

1. Noun. (enzyme) Any of a family of enzymes that regulate calcium in the body ¹



¹ Source: wiktionary.com

Definition of Calpain

1. an enzyme for digesting proteins [n -S]

Medical Definition of Calpain

1. Calcium activated cytoplasmic proteases containing the EF hand motif. Calpain I is activated by micromolar calcium, Calpain II by millimolar calcium. Calpain has two subunits, the larger (80 kD) has 4 domains one homologous with papain, one with calmodulin, the smaller (30 kD) has one domain homologous with calmodulin. First isolated from erythrocytes, but now described from other cells. (13 Oct 1997)

Calpain Pictures

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Lexicographical Neighbors of Calpain

calotte model
calottes
calotype
calotypes
calotypist
calotypists
caloyer
caloyers
calp
calpa
calpac
calpack
calpacks
calpacs
calpactin
calpain (current term)
calpains
calpas
calpastatin
calpeptin
calphobindins
calpolli
calpollis
calpoltin
calponin
calprotectin
calps
calque
calqued
calques

Literary usage of Calpain

Below you will find example usage of this term as found in modern and/or classical literature:

1. Molecular Neurobiology: Proceedings of the Second Nimh Conference by Steven Zalcman (1995)
"The Ca^-activated neutral protease calpain is unleashed by glutamate receptor ... calpain inhibitors have been recently found to be neuroprotective in ..."

2. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Miller AC, Schattenberg DG, Malkinson AM, Ross D. Decreased content of the IL-1 alpha processing enzyme calpain in murine bone marrow-derived macrophages ..."

3. Meeting the Challenge: U. S. Industry Faces the 21st Century: The U. S by Jon Paugh (1998)
"Finally, Cephalon and SmithKline Beecham are collaborating to develop inhibitors of the enzyme calpain, which causes damage to nerve cells when a stroke ..."

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