Definition of Castleman's disease
1. Noun. A rare lymphoproliferative disorder involving hyperproliferation of certain B cells that often produce cytokines. ¹
¹ Source: wiktionary.com
Medical Definition of Castleman's disease
1. Solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma. Synonym: angiofollicular mediastinal lymph node hyperplasia, Castleman's disease. (05 Mar 2000)
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