Lexic.us

Medical Definition of Cd80

1. The natural ligand for the T-cell antigen CD28 (antigens, CD28) mediating t-cell and B-cell adhesion. Cd80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes. The binding of CD80 to CD28 and ctla-4 provides a co-stimulatory signal to T-cells and leads to greatly upregulated lymphokine production. (12 Dec 1998)

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