Definition of Cilastatin

1. Noun. (medicine) A dehydropeptidase inhibitor that is used in association with certain antibiotics to prevent them being inactivated ¹



¹ Source: wiktionary.com

Medical Definition of Cilastatin

1. A renal dehydropeptidase-I and leukotriene d4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene d4 to leukeotriene e4. Pharmacological action: protease inhibitors. Chemical name: 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))- (12 Dec 1998)

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Lexicographical Neighbors of Cilastatin

cigarmakers
cigarmaking
cigars
ciggie
ciggies
ciggy
cigs
ciguatera
ciguateras
ciguateratoxin
ciguateratoxins
ciguatoxin
ciguatoxins
cilantro
cilantros
cilastatin (current term)
cilastatin sodium
cilazapril
cilia
cilial
ciliary
ciliary arteries
ciliary artery
ciliary blepharitis
ciliary bodies
ciliary body
ciliary border of iris
ciliary canals
ciliary cartilage
ciliary crown

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