Medical Definition of Dideoxyadenosine

1. A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolised to didanosine (ddi) by enzymatic deamination; ddi is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite. Pharmacological action: antimetabolites, antiviral agents. Chemical name: Adenosine, 2',3'-dideoxy- (12 Dec 1998)



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Lexicographical Neighbors of Dideoxyadenosine

didees
didelphia
didelphian
didelphic
didelphid
didelphids
didelphine
didelphous
didelphyc
didemnaketal
didemnaketals
didendron
dideoxy
dideoxy procedure
dideoxy sequencing
dideoxyadenosine (current term)
dideoxycytidine
dideoxyinosine
dideoxynucleosides
dideoxynucleotide
dideoxynucleotides
dideoxyribonucleoside
dideoxyribonucleosides
dideoxysugar
dideoxysugars
dideoxythymidine
didesmethyldoxylamine
didgeridoo
didgeridooer
didgeridooist

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