Medical Definition of Endothelium-derived relaxing factor

1. A labile humoral agent released by the vascular endothelium that mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin. Edrf also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. These actions are believed to be mediated through stimulation of guanylate cyclase and the consequent elevation of cyclic guanosine 3',5'-monophosphate. Edrf is thought to be nitric oxide or a ready source of it. The factor is believed to be unstable and acts only locally in vivo. (12 Dec 1998)



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Lexicographical Neighbors of Endothelium-derived Relaxing Factor

endothelin-valine-generating endopeptidase
endothelin receptor
endothelins
endothelio-endothelial placenta
endotheliochorial placenta
endotheliocyte
endothelioid
endothelioma
endotheliomas
endotheliomata
endotheliosis
endotheliotoxin
endotheliotropic
endothelium
endothelium-derived growth factor synthase
endothelium-derived relaxing factor (current term)
endothelium camerae anterioris
endothelium derived relaxation factor
endothelium of anterior chamber
endotheloid
endotherm
endothermal
endothermic
endothermic reaction
endothermically
endothermicity
endothermies
endotherms
endothermy
endothoracic fascia

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