Medical Definition of Giant cell granuloma
1.
A non-neoplastic lesion characterised by a proliferation of granulation tissue containing numerous multinucleated giant cells.
It occurs on the gingiva and alveolar mucosa (occasionally on other soft tissues) where it presents as a soft red-blue haemorrhagic nodular swelling. It also occurs within the mandible or maxilla as a unilocular or multilocular radiolucency.
Peripheral giant cell granuloma refers to the gingiva (giant cell epulis), central refers to the jaw.
Microscopically similar lesions occur in the tubular bones of the hands and feet, are considered neoplastic, and may have a malignant course. Identical bony lesions may be seen in hyperparathyroidism and cherubism.
See: giant cell tumour of bone.
Synonym: giant cell epulis.
(05 Mar 2000)
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