Definition of Hand-schuller-christian disease
1. Noun. Inflammatory histiocytosis associated with disturbance of cholesterol metabolism; occurs chiefly in young children and is characterized by cystic defects of the skull and diabetes insipidus.
Medical Definition of Hand-schuller-christian disease
1. A condition marked by the abnormal appearance of histiocytes (macrophages) in the blood. Lipid h., Niemann-Pick disease. Sinus h., a disorder of the lymph nodes in which the distended sinuses are completely or nearly completely, filled by histiocytes, as a result of active multiplication of the littoral cells. H. X, a generic term embracing eosinophilic granuloma, Letterer-Siwe disease and Hand-Schuller-Christian disease and indicating a shared common origin for the three entities. (16 Dec 1997)
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