Definition of Hexamethonium

1. Noun. (organic chemistry medicine) Any divalent cation derived from hexamethylene diamine, but especially the hexamethyl derivative which is a ganglionic blocker ¹



¹ Source: wiktionary.com

Definition of Hexamethonium

1. [n -S]

Medical Definition of Hexamethonium

1. A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool. Pharmacological action: antihypertensive agents, ganglionic blockers, nicotinic antagonists. Chemical name: 1,6-hexanediaminium, N,N,N,N',N',N'-hexamethyl- (12 Dec 1998)

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Lexicographical Neighbors of Hexamethonium

hexakis-
hexakisphosphate
hexakisphosphates
hexakosioihexekontahexaphobia
hexality
hexalogy
hexamer
hexameric
hexamerous
hexamers
hexametaphosphate
hexametazime
hexameter
hexameters
hexamethone bromide
hexamethonium (current term)
hexamethonium chloride
hexamethonium compounds
hexamethoniums
hexamethoxide
hexamethoxides
hexamethyl
hexamethylbenzene
hexamethylbenzenes
hexamethylcyclotrisiloxane
hexamethylenamin
hexamethylene
hexamethylene diamine
hexamethylene tetramine
hexamethylenediamine

Literary usage of Hexamethonium

Below you will find example usage of this term as found in modern and/or classical literature:

1. Proceedings of the Society for Experimental Biology and Medicine (1903)
"... but not in the animal treated with hexamethonium. Treatment with phentolamine, guanethidine or desmethylimipramine virtually abolished pressor effects ..."

2. Health Consequences of Smoking: Nicotine Addiction a Report of the Surgeon by C. Everett Koop, M.D., DIANE Publishing Company (1988)
"Because mecamylamine, but not hexamethonium, blocks nicotine-conditioned taste aversions, the mechanism by which nicotine conditions taste aversions appears ..."

3. A Lifelong Passion: Nicholas and Alexandra: Their Own Story by Andrei Maylunas (2005)
"Mecamylamine (1.6-3.2 mM) inhibited the population spike, while hexamethonium (3.2 mM) had no effect. These cholinergic antagonists were tested for their ..."

4. Health Consequences of Smoking: Cardiovascular Disease: A Report of the by DIANE Publishing Company, C. Everett Koop, M.D. (1995)
"(112) PACHINGER, O., HELLBERG, KD, BING, RJ The effect of nicotine, propranolol, phentolamine and hexamethonium on the coronary microcirculation of the cat. ..."

5. Drug Abuse and Drug Abuse Research (1991): The Third Triennial Report to edited by MaryLouise Embrey, Christine R. Hartel (1999)
"The increases in blood pressure were even greater when atropine was added to the preparation, but pretreatment with the ganglionic blocker hexamethonium ..."

6. Nicotine in Cigarettes and Smokeless Tobacco Products Is a Drug and These edited by Barry Leonard (1999)
"... the ability of rats to discriminate subcutaneously administered nicotine, and other antagonists that do not enter the brain, such as hexamethonium, ..."

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