Definition of Holoprosencephaly

1. Noun. A congenital disorder involving insufficient division of the lobes of the brain during fetal development, resulting in skull and facial deformities ranging from minor cleft lip problems to cyclopia, in which a single eye develops where the nose would normally be. ¹

¹ Source: wiktionary.com

Medical Definition of Holoprosencephaly

1. Spectrum of craniofacial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. There are three types of malformations based on the degree of failure of separation of the prosencephalon: alobar, semilobar, and lobar. Concurrent facial anomalies can include cyclopia, cleft lip, cleft palate, and hypotelorism. Holoprosencephaly is thought to be a developmental field defect and is associated with chromosomal abnormalities. (12 Dec 1998)

Holoprosencephaly Pictures

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Lexicographical Neighbors of Holoprosencephaly

holoparasitic
holopelagic
holophanerous
holophotal
holophote
holophotes
holophrasis
holophrastic
holophrastically
holophyte
holophytes
holophytic
holoplankton
holoplanktonic
holoprosencephalies
holoprotein
holoptic
holorachischisis
holoreceptor
holoreceptors
holorhinal
holorhyme
holorhymes
holos
holoscopic eyepiece
holoside
holosiderite
holosiderites
holostean

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