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Definition of Hydroxyproline
1. Noun. A crystalline amino acid obtained from gelatin or collagen.
Definition of Hydroxyproline
1. Noun. (biochemistry) A hydroxy derivative of the amino acid ''proline'' found in the structural proteins of connective tissue ¹
¹ Source: wiktionary.com
Definition of Hydroxyproline
1. [n -S]
Medical Definition of Hydroxyproline
1. Specific proline residues on the amino side of a glycine residue in collagen become hydroxylated at C4, before the polypeptides become helical, by the activity of prolyl hydroxylase. This enzyme has a ferrous ion at the active site and a reducing agent such as ascorbate is necessary to maintain the iron in the ferrous state. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls (see HRGP). This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)
Lexicographical Neighbors of Hydroxyproline
Literary usage of Hydroxyproline
Below you will find example usage of this term as found in modern and/or classical literature:
1. Science by American Association for the Advancement of Science (1883)
"Similarly, small amounts of hydroxyproline have been found in the test of the sea
... Samples of echinoid tissues known to contain hydroxyproline (test with ..."
2. Proceedings of the Society for Experimental Biology and Medicine (1903)
"The hydroxyproline content was measured in an aliquot of fluid from a sample
which had been hydrolyzed in 6 A' HC1 at 100° for 17 hr according to the method ..."
3. Osteoporosis Research, Education and Health Promotion (1993)
"Urinary THP consists mainly of hydroxyproline-containing pep- tides of various
lengths derived from collagen catabolism; the amount of free hydroxyproline ..."
4. A Lifelong Passion: Nicholas and Alexandra: Their Own Story by Andrei Maylunas (2005)
"Only the highest concentration of nicotine tested produced substantial effects
as demonstrated by decreased oxygen consumption and (3H)hydroxyproline ..."
5. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Consistent with this, lung hydroxyproline was reduced in ... Effect of chrysotile
asbestos on total lung hydroxyproline 6 weeks postexposure. ..."
6. Air Quality Criteria for Oxides of Nitrogenby Dennis J. Kotchmar by Dennis J. Kotchmar (1996)
"hydroxyproline excretion, an indicator of increased collagen catabolism or connective
... (1986, 1988) found an association between the hydroxyproline to ..."
7. Journal of the American Chemical Society by American Chemical Society (1879)
"... the trans- amide 17, identical in every respect (mixture melting point
undepressed) with material obtained by total synthesis from L-hydroxyproline. ..."
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