Medical Definition of Isocitrate dehydrogenase

1. An enzyme of the oxidoreductase class that catalyses the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires magnesium, mn2+; it is activated by ADP, citrate, and calcium, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (the NADP+ enzyme is EC 1.1.1.42.) Chemical name: Isocitrate:NAD+ oxidoreductase (decarboxylating) Registry number: EC 1.1.1.41 (12 Dec 1998)



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Lexicographical Neighbors of Isocitrate Dehydrogenase

isochrone
isochrones
isochronia
isochronic
isochronism
isochronisms
isochronon
isochronons
isochronous
isochronously
isochrons
isochrony
isochroous
isocitrase
isocitrate
isocitrate dehydrogenase (current term)
isocitrate lyase
isocitrates
isocitric
isocitric acid
isocitric acid dehydrogenase
isocitritase
isoclinal
isoclinals
isocline
isoclined
isoclines
isoclinic
isoclinics
isocola

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