Lexic.us

Definition of Lovastatin

1. Noun. An oral drug (trade name Mevacor) to reduce blood cholesterol levels; used when dietary changes have proved inadequate.

Definition of Lovastatin

1. Noun. (medicine) A statin that inhibits the synthesis of cholesterol ¹

¹ Source: wiktionary.com

Definition of Lovastatin

1. [n -S]

Medical Definition of Lovastatin

1. A fungal metabolite isolated from cultures of aspergillus terreus. The compound is a potent anticholesteraemic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxymethylglutaryl CoA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. Several studies have shown that because of its enzyme inhibitory activity it acts as an antineoplastic agent for certain tumours. Pharmacological action: anticholesteraemic agents, antineoplastic agent, hydroxymethylglutaryl-CoA reductase inhibitors. Chemical name: Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))- (12 Dec 1998)

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Literary usage of Lovastatin

Below you will find example usage of this term as found in modern and/or classical literature:

1. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of ...by Scott M. Grundy by Scott M. Grundy (1997)
"lovastatin therapy in nephrotic hyperlipidemia: effects on lipoprotein ... The effects of lovastatin in hyperlipidemic patients with the nephrotic syndrome. ..."

2. Cholesterol Treatment: A Review of the Clinical Trials Evidence by DIANE Publishing Company (1996)
"... nicotinic acid lovastatin + colestipol; niacin + colestipol' Diet, ... lovastatin' 2.5 9.7 No. of participants 143 8341 188 555 146 48 838 ..."

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