Definition of Macrophage

1. Noun. A large phagocyte; some are fixed and other circulate in the blood stream.

Specialized synonyms: Histiocyte
Generic synonyms: Phagocyte, Scavenger Cell

Definition of Macrophage

1. Noun. (immunology cytology) A white blood cell that phagocytizes necrotic cell debris and foreign material, including viruses, bacteria, and tattoo ink. It presents foreign antigens on MHC II to lymphocytes. Part of the innate immune system. ¹

¹ Source:

Definition of Macrophage

1. [n -S]

Medical Definition of Macrophage

1. Relatively long lived phagocytic cell of mammalian tissues, derived from blood monocyte. Macrophages from different sites have distinctly different properties. Main types are peritoneal and alveolar macrophages, tissue macrophages (histiocytes), Kupffer cells of the liver and osteoclasts. In response to foreign materials may become stimulated or activated. Macrophages play an important role in killing of some bacteria, protozoa and tumour cells, release substances that stimulate other cells of the immune system and are involved in antigen presentation. May further differentiate within chronic inflammatory lesions to epithelioid cells or may fuse to form foreign body giant cells or Langhans giant cells. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Macrophage Pictures

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Lexicographical Neighbors of Macrophage

macrophage (current term)
macrophage-1 antigen
macrophage-activating factor
macrophage activation
macrophage colony-stimulating factor
macrophage inflammatory protein
macrophage inhibition factor
macrophage migration-inhibitory factors
macrophage migration inhibition test

Literary usage of Macrophage

Below you will find example usage of this term as found in modern and/or classical literature:

1. Oxygen/Nitrogen Radicals and Cellular Injury edited by Kenneth B. Adler, Robert D. Devlin, Val Vallyathan (2000)
"Modulation of the Alveolar macrophage Superoxide Production by Protein ... respiratory burst, alveolar macrophage Introduction Phagocytes such as ..."

2. Glossary of HIV/Aids-related Terms edited by Barry Leonard (1995)
"macrophage: A large immune cell that devours invading pathogens and other intruders. Stimulates other immune cells by presenting them with small pieces of ..."

3. Folia Haematologica: Internationales Magazin für klinische und (1908)
"Moelle osseuse de foetus de cobaye, sacrifié peu de jours avant la naissance. Pré- parution par empreinte. Alcool absolu. Giemsa. Cellule macrophage géante ..."

4. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Lehnert B. Pulmonary and thoracic macrophage subpopulations and ... Mechanisms of macrophage accumulation in the lungs of asbestos-exposed subjects. ..."

5. Science by American Association for the Advancement of Science (1883)
"On the other hand, lymphocytes from the spleens of animals immunized with DNP-HGG in nose drops failed to give significant inhibition of macrophage ..."

6. Proceedings of the Society for Experimental Biology and Medicine (1903)
"Little information is available as to whether macrophage antimicrobial mechanisms are also affected by malnutrition. As an important member of primary host ..."

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