Definition of Methotrexate

1. Noun. Toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis.




Definition of Methotrexate

1. Noun. (medicine) An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases. ¹

¹ Source: wiktionary.com

Definition of Methotrexate

1. [n -S]

Medical Definition of Methotrexate

1. Analogue of dihydrofolate. Inhibits dihydrofolate reductase and kills rapidly growing cells. Therapeutic agent for leukaemias, but has a low therapeutic ratio. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Methotrexate Pictures

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Lexicographical Neighbors of Methotrexate

methodology
methods
methohexital
methohexital sodium
methohexitone
methol
methomyl
methonium compounds
methophenazine
methopholine
methoprene
methopterin
methorphan
methorphinan
methoserpidine
methotrexate (current term)
methotrexate sodium
methotrexates
methotrimeprazine
methought
methoxamine
methoxamine hydrochloride
methoxatin
methoxetamine
methoxide
methoxides
methoxsalen
methoxy
methoxy-
methoxyamination

Literary usage of Methotrexate

Below you will find example usage of this term as found in modern and/or classical literature:

1. Operative Gynecologic Laparoscopy: Principles and Techniques by Camran Nezhat (2000)
"Single doses of methotrexate for treatment of ectopic pregnancy. ... Treatment of tubal pregnancy by local injection of methotrexate after adrenaline ..."

2. Science by American Association for the Advancement of Science (1883)
"Cytotoxic agents used and dosage schedules were as follows: Single agents: 1) methotrexate, 20 to 25 mg/day intramuscularly for 5 days; ..."

3. Overview of the Third Text Retrieval Conference (Trec-3) edited by D. K. Harmon (1996)
"They cite an example of the concepts methotrexate and psoriasis and several questions that might be posed by these two concepts: "Does methotrexate cause ..."

4. Approved Drug Products with Therapeutic Equivalence Evaluationsedited by Barry Leonard edited by Barry Leonard (1999)
"Treatment of AIDS myelopathy. Treatment of juvenile rheumatoid arthritis. Treatment of osteogenic sarcoma. methotrexate with ..."

5. Lymphoma Project Report: Current Issues in Research and Treatment of AIDS by Michael Marco (1995)
"18 M-BACOD: M = methotrexate; B = Bleomycin; A = Adriamycin; C = Cyclophosphamide; O = Vincristine; and D =Dexamethasone (a steroid). ..."

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