2. Noun. (genetics) the addition of a methyl group to cytosine and adenine residues in DNA that leads to the epigenetic modification of DNA and the reduction of gene expression and protein production ¹
¹ Source: wiktionary.com
Definition of Methylation
1. [n -S]
Medical Definition of Methylation
1. Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (12 Dec 1998)
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Lexicographical Neighbors of Methylation
Literary usage of Methylation
Below you will find example usage of this term as found in modern and/or classical literature:
1. Mammalian Embryo Genomics by Oecd, (Paris) Organisation for Economic Co-ope, OECD Staff (2003)
"Gene Expression and DNA methylation of an Imprinted Gene Cluster on Ovine Chromosome 18 During Early Embryonic Development RE Durkin, CA Bidwell, ..."
2. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Altered DNA methylation may result in an altered pattern of gene expression ... The phenomenon of de novo methylation provides the potential for reversal of ..."
3. On Aniline and Its Derivatives: A Treatise Upon the Manufacture of Aniline by M. Reimann, August Wilhelm von Hofmann, Georges de Laire (1868)
"Violet Substances obtained by methylation and.Ethy- lation.—The scientific researches which have established the true constitution of the blue colour, ..."
4. Technology of Cellulose Esters: A Theoretical and Practical Treatise on the by Edward Chauncey Worden (1916)
"methylation and Ethylation of Cellulose. L. Lilienfeld has recently described l ethers of cellulose or modified cellu- 1. EP 12854, 1912. ..."
5. Lectures on Chemical Pathology in Its Relation to Practical Medicine by Christian Archibald Herter (1902)
"... its relation to ammonia— methylation—Protection of the organism against presence of free acid—Part played by ammonia and other alkalis—Acid intoxication ..."