Medical Definition of Michaelis constant

1. The true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction (usually symbolised by Ks), the concentration of the substrate at which half the true maximum velocity of an enzyme-catalyzed reaction is achieved (when velocities are measured under initial rate and steady state conditions). The ratio of rate constants (k2 + k3)/k1 in the single-substrate enzyme-catalyzed reaction: E + S &dblarr; ES &dblarr; E + products where E represents the free enzyme, S is the substrate, and ES is the central binary complex. The expression for the Michaelis constant will be more complex for multisubstrate reactions. An apparent Michaelis constant is a constant determined either under conditions that are not strictly steady state and initial rate or one that varies with the concentration of one or more cosubstrates. See: Michaelis-Menten equation. Synonym: Michaelis-Menten constant. (05 Mar 2000)



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Lexicographical Neighbors of Michaelis Constant

Michael
Michael Ellis De Bakey
Michael Faraday
Michael Gerald Tyson
Michael Jackson
Michael Joe Jackson
Michael Ondaatje
Michael Philip Jagger
Michaela
Michaelis-Gutmann body
Michaelis-Menten constant
Michaelis-Menten equation
Michaelis-Menten hypothesis
Michaelis complex
Michaelis constant
Michaell
Michaelmas
Michaelmas Day
Michaelmas daisy
Michaelmastide
Michal
Michalis
Micheal
Micheas
Michel Eyquem Montaigne
Michel Levy scale of retardation colours
Michel Montaigne
Michel Ney
Michel de Notredame

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