Medical Definition of Monod-wyman-changeux model
1. A model used to explain the allosteric form of cooperativity; in this model, an oligomeric protein can exist in two conformational states in the absence of the ligand; these states are in equilibrium and the one that is predominant has a lower affinity for the ligand (which binds to the protein in a rapid equilibrium fashion). Synonym: concerted model. (05 Mar 2000)
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