Medical Definition of Neurofibrillary tangles

1. Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: 1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; 2) the microtubule-associated proteins map-2 and tau; 3) actin; and 4) ubiquitin. As one of the hallmarks of alzheimer disease, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brainstem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of alzheimer disease. (12 Dec 1998)

Lexicographical Neighbors of Neurofibrillary Tangles

neuroethologies
neuroethologist
neuroethologists
neuroethology
neuroevolution
neuroevolutionary
neurofascin
neurofascins
neurofeedback
neurofibril
neurofibrillar
neurofibrillar nerve
neurofibrillary
neurofibrillary degeneration
neurofibrillary tangle
neurofibrillary tangles (current term)
neurofibrils
neurofibroma
neurofibromas
neurofibromata
neurofibromatoses
neurofibromatosis
neurofibromatosis 2
neurofibromin
neurofibromins
neurofibrosarcoma
neurofibrosarcomas
neurofibrosarcomata
neurofilament

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