Medical Definition of Nidogen
1.
A dumbbell shaped 150 kD sulphated glycoprotein that is found in all basement membranes. It binds to laminin, forming a very stable 1:1 complex (KD = 10nM) and almost all laminin preparations contain entactin. The N terminal globular domain can self aggregate, whilst the C terminal globular domain binds to the short arm of laminin and to collagen IV. The connecting rod has 5-6 EGF type cysteine rich repeats, one of which has an RGD sequence for cellular interaction.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
Lexicographical Neighbors of Nidogen
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