Medical Definition of No-observed-adverse-effect level

1. The highest dosage administered that does not produce toxic effects. The noael will depend on how closely dosages are spaced (lowest-observed-adverse-effect level and no-observed-effect level) and the number of animals examined. The ultimate objective is usually to determine not the "safe" dosage in laboratory animals but the "safe" dosage for humans. Therefore, the extrapolation most often required of toxicologists is from high-dosage studies in laboratory animals to low doses in humans. (casarett and doull's toxicology: the basic science of poisons, 4th ed) (12 Dec 1998)



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Lexicographical Neighbors of No-observed-adverse-effect Level

no-hit game
no-hitter
no-hitters
no-holds-barred
no-hoper
no-host
no-life
no-load
no-load fund
no-lone zone
no-lone zones
no-man's-land
no-name
no-no
no-nonsense
no-observed-adverse-effect level (current term)
no-one
no-op
no-ops
no-par-value stock
no-par stock
no-parking zone
no-questions-asked
no-see-um
no-see-ums
no-show
no-shows
no-strings-attached
no-take
no-threshold concept

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