Medical Definition of Paget disease
1.
Disease of unknown aetiology involving destruction and reparation, age greater than 40y; M:F 2:1, skull, osteoporosis circumscripta (outer table destroyed only), cotton wool appearance, increased hat size!, spine, monostotic vertebral involvment usually, pelvis, affected in 2/3 cases, consists of cortical thickening, enlargement of pubis/ischium, coarse trabecular pattern, extremities, blade of grass appearance, elevation of alk phos (up to 20X), normal calcium, normal phosphorus, complications: path fractures in 8% cases (usually femur = shepard's crook), malignant degeneration (usually osteosarcoma-50%, fibrosarcoma-25%)
(12 Dec 1998)
Lexicographical Neighbors of Paget Disease
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