Medical Definition of Paroxysmal nocturnal haemoglobinuria

1. An infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterised by episodes of haemolytic anaemia, haemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly; red blood cells are usually macrocytic and vary considerably in size, but there is no evidence of spherocytosis, erythrophagocytosis, or abnormal leukocytes. The disorder is a result of an abnormality of the red cell membrane which makes the red cell unusually sensitive to lysis by complement. Synonym: Marchiafava-Micheli anaemia, Marchiafava-Micheli syndrome. (05 Mar 2000)



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Lexicographical Neighbors of Paroxysmal Nocturnal Haemoglobinuria

parovarian
parovarian cyst
parovariotomy
parovaritis
parovarium
paroxetime
paroxetine
paroxypropione
paroxysm
paroxysmal
paroxysmal atrial tachycardia
paroxysmal cerebral dysrhythmia
paroxysmal cold haemoglobinuria
paroxysmal nocturnal dyspnea
paroxysmal nocturnal dyspnoea
paroxysmal nocturnal haemoglobinuria (current term)
paroxysmal sleep
paroxysmal tachycardia
paroxysmal trepidant abasia
paroxysmally
paroxysms
paroxytone
paroxytones
paroxytonic
parp
parpane
parpanes
parped
parpen
parpend

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