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Definition of Philosopher's stone
1. Noun. Hypothetical substance that the alchemists believed to be capable of changing base metals into gold.
Medical Definition of Philosopher's stone
1. A stone sought by the alchemists of the Middle Ages which was supposedly able to transmute base metals into gold, to make precious stone's, and to cure all ills, and thus confer longevity; it was also believed to be a universal solvent. (05 Mar 2000)