Definition of Phospholipase

1. Noun. (enzyme) Any of several enzymes that hydrolyze the phosphate ester bonds of phospholipids. ¹

¹ Source:

Definition of Phospholipase

1. [n -S]

Medical Definition of Phospholipase

1. That hydrolyse ester bonds in phospholipids. They comprise two types: aliphatic esterases (phospholipase A1, A2 and B) that release fatty acids and phosphodiesterases (types C and D) that release diacyl glycerol or phosphatidic acid respectively. Type A2 is widely distributed in venoms and digestive secretions. Types A1, A2 and C the latter specific for phosphatidyl inositol) are present in all mammalian tissues. Type C is also found as a highly toxic secretion product of pathogenic bacteria. Type B attacks monoacyl phospholipids and is poorly characterised. Type D is largely of plant origin. PLA2 Type II (a secreted enzyme, but not the same as the Type I digestive pancreatic enzyme) is probably very important in inflammation because its action can release arachidonic acid, the starting point for eicosanoid synthesis. Phosphatidyl inositol bisphosphate specific phospholipase C is important in generating diacyl glycerol and inositol trisphosphate, both second messengers. (31 Dec 1997)

Phospholipase Pictures

Click the following link to bring up a new window with an automated collection of images related to the term: Phospholipase Images

Lexicographical Neighbors of Phospholipase

phospholamban kinase
phospholamban phosphatase
phospholipase (current term)
phospholipase A1
phospholipase A2
phospholipase B
phospholipase c
phospholipase d
phospholipases a
phospholipid-hydroperoxide glutathione peroxidase
phospholipid bilayer
phospholipid ethers
phospholipid syndrome
phospholipid transfer protein

Literary usage of Phospholipase

Below you will find example usage of this term as found in modern and/or classical literature:

1. Oxygen/Nitrogen Radicals and Cellular Injury edited by Kenneth B. Adler, Robert D. Devlin, Val Vallyathan (2000)
"... C, and D. Suramin pretreatment inhibited ROS stimulation of phospholipase D (PLD), suggesting a role for growth factor receptors in this activation. ..."

2. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Lipocortin 1 (also known as annexin l) is a glycosylated 37- kDa Ca2 +-dependent phospholipid-bind- ing protein that inhibits phospholipase A.2, ..."

3. Fluoride in Drinking Water: A Scientific Review of EPA's Standards by Committee on Fluoride in Drinking Water, National Research Council (2006)
"There was in situ activation of nitrogen-activated protein kinase, phospholipase A2, and phosphatidylinositol-phospholipase C. Little or no effect on ..."

Other Resources Relating to: Phospholipase

Search for Phospholipase on!Search for Phospholipase on!Search for Phospholipase on Google!Search for Phospholipase on Wikipedia!