Lexic.us

Definition of Severe combined immunodeficiency

1. Noun. A congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life.

Medical Definition of Severe combined immunodeficiency

1. Group of rare congenital disorders characterised by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an x-linked or autosomal recessive defect. About half of the patients with autosomal recessive scid are deficient in the enzyme adenosine deaminase. (12 Dec 1998)

Lexicographical Neighbors of Severe Combined Immunodeficiency

Literary usage of Severe combined immunodeficiency

Below you will find example usage of this term as found in modern and/or classical literature:

1. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"We examined the role of DNA break repair in ASRs using murine cells deficient (ie, severe combined immunodeficiency [SCID] ceils) or proficient (ie, ..."

2. Understanding the Immune System by Lydia Woods Schindler (1991)
"Very rarely, infants are born lacking all the major immune defenses; this is known as severe combined immunodeficiency disease (SCID). ..."

3. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff, (Paris) Organisation for Economic Co-ope (1998)
"The first used severe combined immunodeficiency mice (SCID) mice that were reconstituted with human peripheral blood mononuclear cells (PBMC) from ..."

4. Microbial and Phenotypic Definition of Rats and Mice: Proceedings of the by National Research Council Staff, ebrary, Inc, National Research Council, International Committee, Commission on Life Sciences, National Academy of Sciences (1999)
"We have developed nude mice, severe combined immunodeficiency disorders (SCID) mice, and several other models from spontaneous mutants that were established ..."

5. Treating Infectious Diseases in a Microbial World: Report of Two Workshops by National Research Council (2006)
"The development of infectious disease models that use severe combined immunodeficiency (SCID) mice in which the immune system is reconstituted with human ..."

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