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Medical Definition of Single-gene diseases
1. Hereditary disorders caused by a change (mutation) in a single gene. There are thousands of single-gene diseases including achondroplastic dwarfism, huntington disease, cystic fibrosis, sickle cell disease, duchenne muscular dystrophy, and haemophilia. Single-gene diseases typically describe classic simple mendelian patterns of inheritance (as autosomal dominant, autosomal recessive, and x-linked traits) by comparison with polygenic diseases. (12 Dec 1998)
Lexicographical Neighbors of Single-gene Diseases
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