Medical Definition of Spongy degeneration
1.
(Canavan disease)
dysmyelinating disease, autosomal recessive, onset at 2 - 9 months, megalencephaly, (Alexander disease only other degenerative neurological disease in infants with big head!), blindness with or without deafness, hypotonia may lead to spasticity, Diagnosis: brain biopsy, centrum semiovale most severely affected
(12 Dec 1998)
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