Medical Definition of Temperature sensitive mutation

1. A type of conditional mutation in organism, somatic cell or virus that makes it possible to study genes whose total inactivation would be lethal. Such ts mutations can also make possible studies of the effect of reversible switching by temperature changes) in expression of the mutated gene. The usual mechanism of temperature sensitivity is that the mutated gene codes for a protein with a temperature dependent conformational instability, so that it possesses normal activity at one temperature (the permissive temperature), but is inactive at a second (nonpermissive) temperature. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



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Lexicographical Neighbors of Temperature Sensitive Mutation

temperateness
temperatenesses
temperative
temperature
temperature-compensated vaporiser
temperature-sensitive mutant
temperature change
temperature coefficient
temperature coefficients
temperature gradient
temperature inversion
temperature midpoint
temperature reduction
temperature scale
temperature sense
temperature sensitive mutation (current term)
temperature spot
temperature unit
temperatures
temperaunce
tempered
temperer
temperers
tempering
temperment
temperments
tempero-mandibular joint
tempero-mandibular joint syndrome
tempers
tempest

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