Medical Definition of Transcriptional silencing
1.
Mechanism of transcriptional control where DNA is bundled into heterochromatin in order to make it permanently inaccessible for future transcription.
Effectively, this allows for memory in the determination of cell fate in developing organisms. In Drosophila, homeotic genes are silenced by members of the Polycomb group of genes.
(17 Mar 1998)
Lexicographical Neighbors of Transcriptional Silencing
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