Medical Definition of Trigramin

1. Peptides found in the venoms of various snakes of the viper family, that inhibit the function of some integrins of the _1 and _3 classes. They were first identified as inhibitors of platelet aggregation and were subsequently shown to bind with high affinity to integrins and to block the interaction of integrins with RGD containing proteins for example they block the binding of the platelet integrin _IIb_3 to fibrinogen. Disintegrins are effective inhibitors at molar concentrations 500-2000x lower than short RGDX peptides. They are cysteine rich peptides ranging from 45 to 84 amino acids in length and almost all of them have a conserved RGD sequence on a _ turn, presumed to be the site that binds to integrins. The assumption is that their biological role in the venom is to inhibit blood clotting. Found in many snake species, where they are called variously albolabrin, applagin, batroxostatin, bitistatin, echistatin, elegantin, flavouridin, halysin, kistrin, triflavin and trigramin. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



Trigramin Pictures

Click the following link to bring up a new window with an automated collection of images related to the term: Trigramin Images

Lexicographical Neighbors of Trigramin

trigonum lumbocostale
trigonum musculare
trigonum nervi hypoglossi
trigonum nervi vagi
trigonum olfactorium
trigonum omoclaviculare
trigonum omotracheale
trigonum palati
trigonum sternocostale
trigonum submandibulare
trigonum submentale
trigonum ventriculi
trigonum vesicae
trigos
trigram
trigramin (current term)
trigrammatic
trigrammic
trigrams
trigraph
trigraphic
trigraphs
trigs
trigyn
trigynia
trigynous
trihalide
trihalides
trihalogenomethane
trihalomethane

Other Resources Relating to: Trigramin

Search for Trigramin on Dictionary.com!Search for Trigramin on Thesaurus.com!Search for Trigramin on Google!Search for Trigramin on Wikipedia!

Search