Definition of Trisomy 21

1. Noun. A congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation.

Definition of Trisomy 21

1. Noun. The presence of three copies of the 21st chromosome in the karyotype. ¹

¹ Source:

Medical Definition of Trisomy 21

1. A congenital condition which is characterised by moderate to severe mental retardation, slanting eyes, a broad short skull, broad hands and short fingers. Other congenital abnormalities include heart defects, oesophageal atresia and an increased incidence of acute lymphocytic leukaemia. All of these findings are secondary to trisomy (an extra chromosome) of the 21st chromosome. Trisomy 21 can be detected in the first few months of pregnancy by amniocentesis. Risk factors include prior Down's child and mothers who become pregnant after age 40. Synonym: Down's syndrome. (27 Sep 1997)

Trisomy 21 Pictures

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Lexicographical Neighbors of Trisomy 21

trisodium orthophosphate
trisodium phosphate
trisomy 18 syndrome
trisomy 20 syndrome
trisomy 21 syndrome
trisomy 8 syndrome
trisomy C syndrome

Literary usage of Trisomy 21

Below you will find example usage of this term as found in modern and/or classical literature:

1. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff, (Paris) Organisation for Economic Co-ope (1998)
"trisomy 21 trisomy 21 is to be included in this overview, not as a cause of AD, but because the post-mortem pathology demonstrates that neuritic plaques and ..."

2. Genetics Testing in the New Millennium: Advances, Standards and Implications edited by Constance A. Morella (2001)
"... Shapiro LR: Increased risk of trisomy 21 offspring to fragile X carrier females? American Journal of Human Genetics 1986;39(3) :137A. 21. ..."

3. Guide To Clinical Preventive Services by U. S. Preventive Services Task Force (1989)
"... 10 oral cancer 15 pancreatic cancer 14 peripheral arterial disease 5 Tonometry 32 Tooth brushing 55 Toxemia of pregnancy 35 Trisomy-21 38 Tubal ligation ..."

4. Rice Genetics: Proceedings of the International Rice Workshop at Lusaka by International Rice Research Institute (1986)
"Familial mongolism (trisomy-21 syndrome) resulting from a "15/21" chromosome translocation in more than three generations of a large kindred. ..."

5. Fluoride in Drinking Water: A Scientific Review of EPA's Standards by Committee on Fluoride in Drinking Water, National Research Council (2006)
"Risk factors for trisomy 21: Maternal cigarette smoking and oral contraceptive use in a population-based case-control study. Genet. Med. l(3):80-88. ..."

6. Proposed National Strategies For The Prevention Of Leading Work-related (1988)
"trisomy 21 (associated with Downs syndrome) is a well-known example. Single-gene mutations may be dominant (expressed if only a single copy is present), ..."

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