Medical Definition of Wobble hypothesis
Explains why the base Inosine is included in position 1 in the anticodons of various t RNAs, why many mRNA codon words translate to a single amino acid, why there are appreciably fewer t RNAs than mRNA codon types and why the redundant nature of the genetic code translates into a precise set of 20 amino acids.
Inosine in Position 1 in the anticodon can base pair with A, u or C in position 3 in the mRNA codon, so that for example UCU, UCC, UCA all code for Serine using an inosine anticodon.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
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