Medical Definition of Yorke's autolytic reaction
1. A test for paroxysmal haemoglobinuria; serum is placed in an ice chest and kept at 0°C for 5 to 7 minutes, then in an incubator at 37°C with erythrocytes for 1 hour, at which time, if the reaction is positive, haemolysis occurs; if the serum is kept at 1°C for an hour and then placed in the incubator with erythrocytes there is little haemolysis. (05 Mar 2000)
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