Medical Definition of Okazaki fragments

1. Short fragments of newly synthesised DNA strands produced during DNA replication. All the known DNA polymerases can only synthesis DNA in one direction, the 5' to 3' direction. However as the strands separate, replication forks will be moving along one parental strand in the 3' to 5' direction and 5' to 3' on the other parental strand. On the former, the leading strand, DNA can be synthesised continuously in the 5' to 3' direction. On the other, the lagging strand, DNA synthesis can only occur when a stretch of single stranded DNA has been exposed and proceeds in the direction opposite to the movement of the replication fork (still 5' to 3). It is thus discontinuous and the series of fragments are then covalently linked by ligases to give a continuous strand. Such fragments were first observed by Okazaki using pulse labelling with radioactive thymidine. In eukaryotes, Okazaki fragments are typically a few hundred nucleotides long, whereas in prokaryotes they may contain several thousands of nucleotides. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Okazaki Fragments

Oireachtas
Oita
Ojibwa
Ojibway
Ojibwe
Ojos Azules
Ojos del Salado
Oka
Okapia
Okapia johnstoni
Okarito brown kiwi
Okarito brown kiwis
Okayama
Okazaki
Okazaki fragment
Okazaki fragments (current term)
Okeechobee
Okefenokee Swamp
Oken
Okenfuss
Okie
Okies
Okinawa
Okinawa campaign
Okinawan
Okinawans
Okla.
Oklahoma
Oklahoma City
Oklahoma land rush

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