Medical Definition of Alpha-1 antitrypsin
1.
Plasma glycoprotein member of the serpin superfamily which inhibits trypsin, neutrophil elastase, and other proteolytic enzymes. Commonly referred to as alpha 1-proteinase inhibitor (a1pi), it exists in over 30 different biochemical variant forms known collectively as the pi (protease inhibitor) system.
Hereditary deficiency is associated with pulmonary emphysema.
See: alpha-1 antitrypsin deficiency
Pharmacological action: serine proteinase inhibitors, trypsin inhibitors.
(12 Dec 1998)
Lexicographical Neighbors of Alpha-1 Antitrypsin
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