Definition of Cd4

1. Noun. A glycoprotein that is found primarily on the surface of helper T cells. "CD4 is a receptor for HIV in humans"

Exact synonyms: Cluster Of Differentiation 4
Generic synonyms: Glycoprotein

Definition of Cd4

1. Abbreviation. (immunology) A glycoprotein found on the surface of helper T cells; in humans, it enables the HIV virus to enter a cell ¹

¹ Source: wiktionary.com

Medical Definition of Cd4

1. 55-kD glycoproteins originally defined as differentiation antigens on T-lymphocytes, but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (major histocompatibility complex) class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. Cd4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV. The protein structure on the surface of a human cell that allows HIV to attach, enter, and thus infect a cell. CD4 receptors are present on CD4 cells (helper T-cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T-cell receptor) through which Tcells and other cells signal each other. (12 Dec 1998)

Lexicographical Neighbors of Cd4

CD14
CD15
CD18
CD19
CD2
CD20
CD26
CD27
CD28
CD29
CD3
CD30
CD31
CD34
CD36
CD4
CD4-positive T-lymphocytes
CD4/CD8 count
CD40
CD44
CD45
CD45 phosphatase
CD4:CD8 ratio
CD4 T cell
CD4 cell
CD4 cell count
CD4 immunoadhesins
CD4 lymphocyte
CD4 lymphocyte count
CD5

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