Definition of Cyclin

1. Noun. (protein) Any of a group of proteins whose presence in a cell varies through its cycle, and that regulates this cycle by forming a complex with kinase ¹

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Definition of Cyclin

1. any of a group of proteins that control the cell cycle [n -S]

Medical Definition of Cyclin

1. Proteins (A and B forms known) whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are though to drive cells into G2 phase and thus to mitosis. Cyclins combine with p34 kinase (cdc2) to form maturation-promoting factor (MPF). See: M phase promoting factor. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Cyclin Pictures

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Lexicographical Neighbors of Cyclin

cyclic redundancy checks
cyclic strabismus
cyclical unemployment
cyclin (current term)
cyclin-dependent kinases
cyclin E-dependent kinase
cyclin a
cyclin b
cyclin d1
cyclin e

Literary usage of Cyclin

Below you will find example usage of this term as found in modern and/or classical literature:

1. Genomic Signal Processing and Statistics by R. Dougherty, Edward R Dougherty (2005)
"CDK2/cyclin E is regulated by two switches: the positive switch complex called ... The CAK complex can be composed oftwo gene products: cyclin H and CDK7. ..."

2. A Lifelong Passion: Nicholas and Alexandra: Their Own Story by Andrei Maylunas (2005)
"Proliferating-cell nuclear antigen (PCNA; also called cyclin) was originally described in proliferating mammalian cells as a nuclear protein with an ..."

3. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Furthermore, we showed that ASRs result from altered G-ยก checkpoint regulation, possibly mediated by overexpression of cyclin D1, proliferating cell nuclear ..."

4. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff (1998)
"In contrast to our expectations, mutant cells have higher levels of cyclin E and even the proposed AP- 1 target gene, cyclin Dl . However, the associated ..."

5. Clinical Research: Hearing Before the Committee on Appropriations, U.S. Senate edited by Mark O. Hatfield (1996)
"Our first product is a test for breast cancer based on cyclin E, a protein that was ... cyclin E has a major role in the regulation of cell proliferation. ..."

6. Mammalian Embryo Genomics by OECD (2003)
"Transcripts analyzed were GDF-9, an oocyte-exclusively expressed gene that plays an important role during follicle development; and cyclin A, involved in ..."

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