Lexic.us

Definition of Cyclooxygenase

1. Noun. Either of two related enzymes that control the production of prostaglandins and are blocked by aspirin.

Definition of Cyclooxygenase

1. Noun. (enzyme) Any of several enzymes that catalyze the conversion of arachidonic acid into prostaglandins; their inhibition is the mode of action of aspirin and ibuprofen. ¹

¹ Source: wiktionary.com

Medical Definition of Cyclooxygenase

1. An enzyme protein complex present in most tissues that catalyses two steps in prostaglandin biosynthesis and produces prostaglandins and thromboxanes from arachidonic acid. The cyclooxygenase activity converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2. The cyclooxygenase activity is inhibited by aspirin like drugs, accounting for their anti-inflammatory effects. Synonym: prostaglandin endoperoxide synthase. (05 Mar 2000)

Lexicographical Neighbors of Cyclooxygenase

Literary usage of Cyclooxygenase

Below you will find example usage of this term as found in modern and/or classical literature:

1. A Lifelong Passion: Nicholas and Alexandra: Their Own Story by Andrei Maylunas (2005)
"In addition, AMs from smokers synthesized less of total cyclooxygenase and ... Furthermore the metabolism of exogenous AA to both cyclooxygenase and ..."

2. Oxygen/Nitrogen Radicals and Cellular Injury edited by Kenneth B. Adler, Robert D. Devlin, Val Vallyathan (2000)
"Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and inter- leukin-6 by rat Kupffer cells. J Leukoc Biol 53:165—172 (1993). 49. ..."

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