Lexic.us

¹ Source: wiktionary.com

Definition of Glutathione

1. [n -S]

Medical Definition of Glutathione

1. The tripeptide _ glutamylcysteinylglycine. It contains an unusual peptide linkage between the _ carboxyl group of the glutamate side chain and the amine group of cysteine. The concentration of glutathione in animal cells is _5mM and its sulphydryl group is kept largely in the reduced state. This allows it to act as a sulphydryl buffer, reducing any disulphide bonds formed within cytoplasmic proteins to cysteines. Hence, few, if any, cytoplasmic proteins contain disulphide bonds. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids and participates in leucotriene synthesis. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Glutathione

Literary usage of Glutathione

Below you will find example usage of this term as found in modern and/or classical literature:

1. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"The glutathione-S-transferase, a group of multifunctional detoxification proteins ... Sies H, Ketterer B. glutathione Conjugation: Mechanisms and Biological ..."

2. Oxidations and Reductions in the Animal Body by Henry Drysdale Dakin (1922)
"The function of the glutathione is thus essentially catalytic and the ... Yeast furnishes useful material for the preparation of glutathione though animal ..."

3. Proceedings of the Fifth International Symposium on Protection Against by DIANE Publishing Company (1996)
"At the end of perfusion, lungs were frozen with liquid N2 and analyzed for total glutathione (GSH) and malondialdehyde (MDA). ..."

4. Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues by National Research Council (U.S.) (2006)
"glutathione-Dependent Metabolism: Tissue, Sex, and Species Differences The liver and kidneys are the major sites of glutathione conjugation. ..."

5. Journal of the American Chemical Society by American Chemical Society (1879)
"L-Cystine, oxidized glutathione, and reduced glutathione were purchased from the Mann Research Laboratories, Inc. The cystine and oxidized ..."

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