Medical Definition of Heat-shock protein

1. Families of proteins conserved through prokaryotic and eukaryotic cells and bacteria in response to hyperthermia and other environmental stresses, although some are constitutively expressed. They increase thermal tolerance and perform functions essential to cell survival under these conditions. Some serve to stabilise proteins in abnormal configurations, play a role in folding and unfolding of proteins and the assembly of oligomeric complexes and may act as chaperonins. Hsp90 complexes with inactive steroid hormone receptor and is displaced upon ligand binding. Four major sub classes are recognised: hsp90, hsp70, hsp60 and small hsps. Hsps have been suggested to act as major immunogens in many infections. Acronym: HSP (12 Dec 1998)

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Lexicographical Neighbors of Heat-shock Protein

heat-curing resin
heat-rigor point
heat-seeking missile
heat-shock factor
heat-shock gene
heat-shock protein (current term)
heat-shock protein 27 kinase
heat-shock proteins 70
heat-shock proteins 90
heat-shock response
heat-shock response element
heat-stable enzyme
heat apoplexy
heat barrier
heat capacities
heat capacity
heat coagulation test
heat content
heat cramp

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