Medical Definition of Impermeable cell junctions

1. Specialised intercellular junction in which the two plasma membranes are separated by only 1-2nm. Found near the apical surface of cells in simple epithelia, forms a sealing gasket around the cell. Prevents fluid moving through the intercellular gap and the lateral diffusion of intrinsic membrane proteins between apical and baso lateral domains of the plasma membrane. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



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