Medical Definition of P53

1. A gene which encodes a protein that regulates cell growth and is able to cause potentially cancerous cells to destroy themselves. In humans it is a 393 residue phosphoprotein that is a tumour suppressor gene rather than an oncogene, as it is frequently inactivated or mutated in tumours and transformed cells. The gene is an antioncogene, and is often found mutated in smokers with lung cancer by a compound found in tobacco smoke, a polycyclic aromatic hydrocarbon called benzo[a]pyrene. The protein it encodes is a phosphoprotein that is 53 kilodaltons in mass. (24 Mar 1998)



Lexicographical Neighbors of P53

p.pr.
p107
p13n
p150 protein kinase
p21(ras) farnesyl-protein transferase
p24
p260 palmitoyltransferase
p270 palmitoyltransferase
p34PSK-J3 kinase
p34 kinase
p34cdc28 kinase
p35
p36
p42(mapk) kinase
p49 3F12 kinase
p53 (current term)
p53-activating kinase
p54 protein kinase
p57 serine proteinase
p57lck
p65
p67 deglycosylase
p68
p68 RNA helicase
p70
p870
pCO2
pET plasmid
pH

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