Medical Definition of Peptidyl-dipeptidase A
1.
A hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine.
An important step in the metabolism of certain vasopressor agents.
It is a chloride-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline. It may also have endopeptidase activity on some substrates.
Registry number: EC 3.4.15.1
Synonym: carboxycathepsin, dipeptidyl carboxypeptidase, kinase II, peptidase P.
(22 Sep 2002)
Lexicographical Neighbors of Peptidyl-dipeptidase A
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