Medical Definition of Pertussis toxin
1.
Protein complex (ca 117 kD). An A B toxin, the active subunit is a single polypeptide 28 kD), the binding subunit a pentamer (two heterodimers, 23 + 11.7 kD, 11.7 + 22 kD and a monomer (9.3 kD) that binds the heterodimers). The active subunit ADP ribosylates the _ subunit of the inhibitory GTP-binding protein (Gi). Crucial to the pathogenicity of Bordetella pertussis, the causative agent of whooping cough.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
Lexicographical Neighbors of Pertussis Toxin
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