Lexic.us

¹ Source: wiktionary.com

Definition of Phospholipase

1. [n -S]

Medical Definition of Phospholipase

1. That hydrolyse ester bonds in phospholipids. They comprise two types: aliphatic esterases (phospholipase A1, A2 and B) that release fatty acids and phosphodiesterases (types C and D) that release diacyl glycerol or phosphatidic acid respectively. Type A2 is widely distributed in venoms and digestive secretions. Types A1, A2 and C the latter specific for phosphatidyl inositol) are present in all mammalian tissues. Type C is also found as a highly toxic secretion product of pathogenic bacteria. Type B attacks monoacyl phospholipids and is poorly characterised. Type D is largely of plant origin. PLA2 Type II (a secreted enzyme, but not the same as the Type I digestive pancreatic enzyme) is probably very important in inflammation because its action can release arachidonic acid, the starting point for eicosanoid synthesis. Phosphatidyl inositol bisphosphate specific phospholipase C is important in generating diacyl glycerol and inositol trisphosphate, both second messengers. (31 Dec 1997)

Lexicographical Neighbors of Phospholipase

Literary usage of Phospholipase

Below you will find example usage of this term as found in modern and/or classical literature:

1. Oxygen/Nitrogen Radicals and Cellular Injury edited by Kenneth B. Adler, Robert D. Devlin, Val Vallyathan (2000)
"... C, and D. Suramin pretreatment inhibited ROS stimulation of phospholipase D (PLD), suggesting a role for growth factor receptors in this activation. ..."

2. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Lipocortin 1 (also known as annexin l) is a glycosylated 37- kDa Ca2 +-dependent phospholipid-bind- ing protein that inhibits phospholipase A.2, ..."

3. Fluoride in Drinking Water: A Scientific Review of EPA's Standards by Committee on Fluoride in Drinking Water, National Research Council (2006)
"There was in situ activation of nitrogen-activated protein kinase, phospholipase A2, and phosphatidylinositol-phospholipase C. Little or no effect on ..."

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